ARESTEARESTE

Applied Research in Science and TechnologyApplied Research in Science and Technology

Hyperuricemia is a pathological condition characterized by increased blood uric acid levels exceeding 7 mg/dL. The use of medicinal plants for managing hyperuricemia has garnered significant attention. This study aims to evaluate the anti-hyperuricemic effect of lemongrass extract (Cymbopogon citratus) in a hyperuricemia model using 18 Deutsche Denken Yoken (DDY) mice induced with potassium oxonate and chicken liver juice. Lemongrass simplicia was extracted by maceration using 96% ethanol. Test animals were divided into six test groups, namely group 1 was the normal; group 2 was the negative control; group 3 was the positive control (allopurinol at 13 mg/kg BW); groups 4 – 6 were treatment lemongrass extract at doses of 350, 700, and 910 mg/kg BW, respectively. The results showed that group 6 mice statistically significantly reduced uric acid levels (p = 0.001, p < 0.05). Cymbopogon citratus extract effectively reduces uric acid levels and holds substantial potential as a uric acid-lowering agent, supporting its empirical use in managing hyperuricemia.

The study concludes that Cymbopogon citratus extract contains flavonoids, alkaloids, tannins, saponins, and terpenoids, with a total flavonoid content of 4.Induction of hyperuricemia using potassium oxonate and chicken liver juice successfully increased uric acid levels in mice.Administration of Cymbopogon citratus extract at a dose of 910 mg/kg BW significantly reduced uric acid levels in male DDY mice, demonstrating its potential as an anti-hyperuricemia agent.

Penelitian lebih lanjut perlu dilakukan untuk menguji efektivitas berbagai metode ekstraksi terhadap kandungan senyawa aktif dan aktivitas antihiperurisemia ekstrak sereh. Studi komparatif perlu dilakukan untuk membandingkan efektivitas ekstrak sereh dengan obat-obatan antihiperurisemia yang sudah ada, seperti allopurinol, dalam model hewan yang lebih kompleks dan relevan secara klinis. Selain itu, penelitian lebih lanjut diperlukan untuk mengidentifikasi dan mengisolasi senyawa aktif spesifik dalam ekstrak sereh yang bertanggung jawab atas efek antihiperurisemia, serta untuk memahami mekanisme molekuler yang mendasari efek tersebut, termasuk interaksi dengan enzim xanthine oxidase dan jalur metabolisme purin lainnya. Penelitian toksisitas jangka panjang juga penting untuk memastikan keamanan penggunaan ekstrak sereh sebagai agen terapeutik, serta studi klinis pada manusia diperlukan untuk mengkonfirmasi efektivitas dan keamanannya dalam mengelola hiperurisemia dan gout.

  1. Dose Optimization of Antihyperuricemia Effects of Matoa Leaf (Pometia pinnata J.R.Forst & G.Forst)... doi.org/10.33096/pharmrep.v2i2.271Dose Optimization of Antihyperuricemia Effects of Matoa Leaf Pometia pinnata J R Forst G Forst doi 10 33096 pharmrep v2i2 271
  2. DETERMINATION OF TOTAL FLAVONOID IN JAMU “X” WITH UV-VISIBLE SPECTROPHOTOMETRIC METHODS |... doi.org/10.31603/pharmacy.v8i2.6864DETERMINATION OF TOTAL FLAVONOID IN JAMU AuXAy WITH UV VISIBLE SPECTROPHOTOMETRIC METHODS doi 10 31603 pharmacy v8i2 6864
Read online
File size384.59 KB
Pages12
DMCAReport

Related /

ads-block-test