UNIVMEDUNIVMED

Universa MedicinaUniversa Medicina

Diethylene glycol (DEG) is a contaminant in pharmaceutical solvents and potentially induces hepatotoxicity. Celery is hepatoprotective due to its antioxidant properties. The objective of this study was to evaluate the hepatoprotective effects of celery on DEG-induced liver injury in rats. An experimental laboratory study was conducted involving 25 male Wistar rats weighing 200 grams. They were randomized into five groups (5 rats in each group). Group A served as the control group, while Group B received oral administration of DEG at a dose of 3 g/kg BW twice daily for three days, following six days of food and water administration. The other three groups received DEG at 3 g/kg BW following six days of celery extract once daily administration of 100 mg/kg BW (C), 200 mg/kg BW (D), and 400 mg/kg BW (E). After 14 days, all rats were sacrificed. Observations were conducted macroscopically and microscopically using H&E staining. Liver damage was scored, Kruskal-Wallis followed by the Mann-Whitney was used to analyze the data. Macroscopic and microscopic examinations of the liver tissue in the celery groups revealed normal histological architecture with a significant reduction in liver damage. The ethanol extract of celery demonstrated hepatoprotective effects, as evidenced by a statistically significant reduction (p<0.05) in the activation of Kupffer cells, sinusoidal dilation, hepatocyte degeneration, and necrosis.

Celery possesses a protective effect against DEG-induced liver damage in rats, as indicated by the reduction in Kupffer cell activation, sinusoidal dilation, hepatocyte degeneration, and necrosis.This study confirms the hepatoprotective properties of celery, aligning with previous research utilizing different toxic agents.The use of diethylene glycol distinguishes this study from prior investigations, motivated by the fatalities caused by DEG poisoning in syrup preparations in Indonesia in 2022.

Penelitian lebih lanjut perlu dilakukan untuk menguji efektivitas ekstrak seledri dalam melindungi hati dari kerusakan akibat DEG pada model hewan yang lebih kompleks, seperti dengan menggunakan berbagai dosis dan durasi pemberian. Studi komparatif perlu dilakukan untuk membandingkan efektivitas ekstrak seledri dengan obat-obatan hepatoprotektor yang sudah ada, guna menentukan potensi sinergis atau keunggulan relatifnya. Selain itu, penelitian lebih lanjut diperlukan untuk mengidentifikasi senyawa bioaktif spesifik dalam seledri yang bertanggung jawab atas efek hepatoprotektifnya, serta mekanisme molekuler yang mendasari efek tersebut, sehingga dapat dikembangkan terapi yang lebih efektif dan terarah untuk mengatasi kerusakan hati akibat paparan DEG atau toksin lainnya.

  1. How Should Regulators and Manufacturers Prevent Avoidable Deaths of Children From Contaminated Cough... doi.org/10.1001/amajethics.2024.289How Should Regulators and Manufacturers Prevent Avoidable Deaths of Children From Contaminated Cough doi 10 1001 amajethics 2024 289
  2. Pathogenesis of Kupffer Cells in Cholestatic Liver Injury - The American Journal of Pathology. pathogenesis... linkinghub.elsevier.com/retrieve/pii/S0002944016302140Pathogenesis of Kupffer Cells in Cholestatic Liver Injury The American Journal of Pathology pathogenesis linkinghub elsevier retrieve pii S0002944016302140
  3. PENGARUH PEMBERIAN TUAK TERHADAP GAMBARAN HISTOPATOLOGI HATI MENCIT (Mus musculus) ICR JANTAN | Sijid... doi.org/10.26418/jpmipa.v11i2.36623PENGARUH PEMBERIAN TUAK TERHADAP GAMBARAN HISTOPATOLOGI HATI MENCIT Mus musculus ICR JANTAN Sijid doi 10 26418 jpmipa v11i2 36623
  4. Pharmacognosy Reviews - An Open Access, Peer Reviewed Journal in the field of Pharmacognosy. reviews... doi.org/10.4103/phrev.phrev_52_17Pharmacognosy Reviews An Open Access Peer Reviewed Journal in the field of Pharmacognosy reviews doi 10 4103 phrev phrev 52 17
  5. 26. GAMBARAN HISTOPATOLOGIS GINJAL TIKUS PUTIH (Rattus novergicus) JANTAN YANG DIINFEKSIKAN Trypanosoma... jurnal.usk.ac.id/JMV/article/view/438626 GAMBARAN HISTOPATOLOGIS GINJAL TIKUS PUTIH Rattus novergicus JANTAN YANG DIINFEKSIKAN Trypanosoma jurnal usk ac JMV article view 4386
Read online
File size562.8 KB
Pages9
DMCAReport

Related /

JURIS Nephroprotective Effect and Untargeted Metabolomic Analysis of Celery Extract Against Diethylene Glycol Induced Nephrotoxicity in Rats 2026More at 2026

UNIVMEDUNIVMED DEG menyebabkan peningkatan kadar triptofan dan fenilalanin sebanyak 45 kali lipat dan 123 kali lipat, masing-masing. Seledri menurunkan kadar metabolitDEG menyebabkan peningkatan kadar triptofan dan fenilalanin sebanyak 45 kali lipat dan 123 kali lipat, masing-masing. Seledri menurunkan kadar metabolit

JURIS Threat Of Zoonotic Malaria And Strategy To Overcome In Kalimantan Indonesian Borneo Bordering Malaysian Borneo 2026More at 2026

UNIVMEDUNIVMED Kasus malaria di Kalimantan (Borneo Indonesia) telah mengalami penurunan selama dua dekade terakhir. Hampir semua kabupaten di provinsi-provinsi tersebutKasus malaria di Kalimantan (Borneo Indonesia) telah mengalami penurunan selama dua dekade terakhir. Hampir semua kabupaten di provinsi-provinsi tersebut

JURIS Predictors Of Persistent High Disease Activity After Methotrexate Treatment In Rheumatoid Arthritis Patients 2026More at 2026

UNIVMEDUNIVMED 48; 95% CI 0. 24–0. 94; p=0. 038); cumulative MTX dose >85 mg (AOR 4. 75; 95% CI 1. 55–14.64; p=0. 006); ESR >66 mm/hr (AOR 2. 32; 95% CI 1. 11–4.48; 95% CI 0. 24–0. 94; p=0. 038); cumulative MTX dose >85 mg (AOR 4. 75; 95% CI 1. 55–14.64; p=0. 006); ESR >66 mm/hr (AOR 2. 32; 95% CI 1. 11–4.

JURIS Gamma oryzanol a novel promising supplement for diabetes mellitus 2025More at 2025

UNIVMEDUNIVMED Tinjauan ini menegaskan potensi terapeutik γ-ORZ dalam pengelolaan diabetes dan komplikasinya, sekaligus menekankan perlunya penelitian yang lebih kuatTinjauan ini menegaskan potensi terapeutik γ-ORZ dalam pengelolaan diabetes dan komplikasinya, sekaligus menekankan perlunya penelitian yang lebih kuat

JURIS Effect of the family medicine approach in reducing stunting among toddlers 2025More at 2025

UNIVMEDUNIVMED Stunting is still prevalent in Jakarta as the capital city of Indonesia. The studys objective was to evaluate the implementation of the family medicineStunting is still prevalent in Jakarta as the capital city of Indonesia. The studys objective was to evaluate the implementation of the family medicine

JURIS Discordance of HER2 between primary tumors and lymph node metastatic lesions in invasive breast cancer 2025More at 2025

UNIVMEDUNIVMED Evaluasi tersebut direkomendasikan untuk prognosis dan kelangsungan hidup yang lebih baik. Penelitian ini menunjukkan adanya ketidaksesuaian status HER2Evaluasi tersebut direkomendasikan untuk prognosis dan kelangsungan hidup yang lebih baik. Penelitian ini menunjukkan adanya ketidaksesuaian status HER2

JURIS Effect of the Concentration of Added Sugar on Organoleptic Properties of Mangrove Syrup from Sonneratia alba fruit 2022More at 2022

UTUUTU Perlakuan dengan komposisi Sonneratia alba 60% dan gula 40% (P3) mendapatkan nilai tertinggi dalam aspek rasa, warna, dan aroma. Namun, untuk tekstur,Perlakuan dengan komposisi Sonneratia alba 60% dan gula 40% (P3) mendapatkan nilai tertinggi dalam aspek rasa, warna, dan aroma. Namun, untuk tekstur,

JURIS The Effectiveness of Sea Lettuce Ulva Lactuca Water Extract from Aceh Waters as an Anti Obesity 2022More at 2022

UTUUTU Kami mengelompokkan menjadi 7 kelompok, yaitu: Normal Kontrol, Kontrol Positif, Kontrol Perlakuan, P1=kelompok tikus obesitas ekstrak 300 mg/kg, P2=kelompokKami mengelompokkan menjadi 7 kelompok, yaitu: Normal Kontrol, Kontrol Positif, Kontrol Perlakuan, P1=kelompok tikus obesitas ekstrak 300 mg/kg, P2=kelompok

Useful /

JURIS FORMULASI DAN UJI STABILITAS HAND BODY LOTION EKSTRAK TERPURIFIKASI KULIT BAWANG MERAH Allium cepa L SEBAGAI ANTIOKSIDAN 2026More at 2026

UNIVERSITASMULIAUNIVERSITASMULIA Lotion dengan ekstrak kulit bawang merah memiliki aktivitas antioksidan yang signifikan dengan peningkatan persen inhibisi radikal bebas seiring peningkatanLotion dengan ekstrak kulit bawang merah memiliki aktivitas antioksidan yang signifikan dengan peningkatan persen inhibisi radikal bebas seiring peningkatan

JURIS Standardisasi dan Penetapan Kadar Flavonoid Total Ekstrak Propolis Trigona Sp Asal Balikpapan 2026More at 2026

UNIVERSITASMULIAUNIVERSITASMULIA Selain itu, propolis mengandung senyawa metabolit sekunder seperti flavonoid, alkaloid, tanin, dan saponin. Karena kandungannya yang bermanfaat, propolisSelain itu, propolis mengandung senyawa metabolit sekunder seperti flavonoid, alkaloid, tanin, dan saponin. Karena kandungannya yang bermanfaat, propolis

JURIS Quincke s disease a rare clinical disorder a case report 2025More at 2025

UNIVMEDUNIVMED Kesimpulan: Kesadaran tentang kondisi langka namun akut ini, bahkan dengan latar belakang etiologi yang tidak diketahui, sangat penting bagi seluruh tenagaKesimpulan: Kesadaran tentang kondisi langka namun akut ini, bahkan dengan latar belakang etiologi yang tidak diketahui, sangat penting bagi seluruh tenaga

JURIS Health Workers in Samarinda City An Examination of Their Distribution Based on Strategic Issues 2022More at 2022

UTUUTU Six sub-districts failed to meet this ratio. Sungai Pinang was the most effective sub-district in achieving the nurse-population balance. Apart from SamarindaSix sub-districts failed to meet this ratio. Sungai Pinang was the most effective sub-district in achieving the nurse-population balance. Apart from Samarinda

ads-block-test