Publisher

JPRJPR

Journal Jurnal Plastik RekonstruksiJurnal Plastik Rekonstruksi Abstract

Introduction: Several studies stated that sucralfate and honey topically promote wound healing process. Sucralfate has been used for stomatitis, excoriation in perianal and peristomal, ulcers, and burn wounds. Honey as a food which is taken orally, is also used topically for several kind of wounds including burn wounds. However, there is no study reviewing sucralfate and honey in burn wounds. Method: Literature review was conducted from 1st until 6th of June 2022 using the terms of “honey, “sucralfate, “burns and “wound healing. Pubmed, Cohrane, Science Direct, Scopus, and Google Scholar were the online data bases we used. We identified eight studies, three trials evaluated the effects of sucralfate in burn wounds and five trials evaluated the effects of honey in burn wounds. Result: 3 Randomized Controlled Trials (RTCs) (n=170) about the effects of sucralfate and 5 RCTs (n=474) reported the effects of honey in burn wounds. Both Sucralfate and Honey group had similar wound healing duration around 18 days and had early sign of wound healing by day 7. Honey has faster complete wound healing compared to sucralfate by day 21. Honey has remarkable antimicrobial effect within one hour. No side effects were reported in both trials. Both honey and sucralfate reduce the necessity for skin grafting.

Conclusion

Both sucralfate and honey exhibit similar rapid re-epithelialization in burn wounds, but honey demonstrates faster complete wound healing by day 21.Both possess comparable antimicrobial effects, report no side effects, and reduce the need for skin grafting.This review highlights the potential of both agents in burn wound management, with honey showing a slight advantage in complete healing time.

Future Research

Penelitian lebih lanjut perlu dilakukan untuk mengeksplorasi efektivitas kombinasi sucralfate dan madu dalam penyembuhan luka bakar, dengan mempertimbangkan potensi efek sinergis dari kedua agen tersebut. Studi prospektif yang lebih besar dan terstruktur dengan baik diperlukan untuk mengidentifikasi subkelompok pasien luka bakar yang paling mungkin mendapatkan manfaat dari terapi sucralfate atau madu, berdasarkan faktor-faktor seperti kedalaman luka, luas permukaan tubuh yang terkena, dan usia pasien. Selain itu, penelitian lebih lanjut harus fokus pada mekanisme molekuler yang mendasari efek penyembuhan luka dari sucralfate dan madu, termasuk dampaknya pada respons inflamasi, angiogenesis, dan deposisi kolagen, untuk mengoptimalkan protokol pengobatan dan mengembangkan terapi inovatif berbasis bukti untuk meningkatkan hasil klinis pada pasien luka bakar.

References

1. Honey compared with silver sulphadiazine in the treatment of superficial partial‐thickness... doi.org/10.1111/j.1742-481X.2010.00717.xHoney compared with silver sulphadiazine in the treatment of superficial partialyAAAathickness doi 10 1111 j 1742 481X 2010 00717 x
2. Sucralfate and Honey in Burn Wound Healing: An Article Review | Jurnal Plastik Rekonstruksi. sucralfate... jprjournal.com/index.php/jpr/article/view/5Sucralfate and Honey in Burn Wound Healing An Article Review Jurnal Plastik Rekonstruksi sucralfate jprjournal index php jpr article view 5

Metadata

File size	508.73 KB
Pages	6
DMCA	Report