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Majalah Obat TradisionalMajalah Obat Tradisional

Chinaberry (Melia azedarach L.) leaves, Malayan cherry (Muntingia calabura L.) fruits, and Yacon (Smallanthus sonchifolius (Poepp.) H.Rob.) leaves are traditionally used by the people of Banyumas (Central Java, Indonesia) to treat diabetes. This study aimed to characterize selected quality parameters, evaluate the in-vitro antioxidant activity as a preliminary assay for its antidiabetic activity, and calculate the total flavonoid content (TFC) and total phenolic content (TPC) of these crude drugs. The plant materials were collected from three different areas in Banyumas and dried into crude drugs. Quality parameters were determined according to the Indonesian Herbal Pharmacopeia (IHP) 2017. Antioxidant activity was evaluated using DPPH scavenging and FRAP assays, while TFC and TPC were analyzed following standard methods in IHP 2017. Correlations between antioxidant activities and TFC-TPC were analyzed by Pearsons correlation test. Yacon leaves and Malayan cherry fruits contained the highest TFC and TPC, respectively. Malayan cherry fruits exhibited the strongest DPPH scavenging activity and FRAP. Moderate to strong correlations were observed between antioxidant activities and TFC-TPC of Malayan cherry fruits and Yacon leaves, suggesting that flavonoids and phenolic compounds contribute to their antioxidant activity.

This study characterized the physicochemical properties of Chinaberry leaf, Malayan cherry fruit, and Yacon leaf crude drugs as initial parameters for their quality.Yacon leaves and Malayan cherry fruits had the highest TFC and TPC, respectively, while Malayan cherry fruits showed the most potent antioxidant activities.The antioxidant activity of both crude drugs was attributable to their flavonoid and phenolic compound contents, suggesting that these compounds play a role in their traditional use for diabetes management.Further research is warranted to investigate the specific mechanisms of action and potential therapeutic applications of these plants.

Berdasarkan penelitian ini, beberapa saran penelitian lanjutan dapat diajukan untuk memperdalam pemahaman tentang potensi tanaman obat tradisional dalam pengelolaan diabetes. Pertama, penelitian lebih lanjut dapat dilakukan untuk mengidentifikasi senyawa bioaktif spesifik dalam daun chinaberry yang berkontribusi pada aktivitas antioksidan, mengingat senyawa tersebut tidak sepenuhnya teridentifikasi dalam penelitian ini. Kedua, penelitian dapat difokuskan pada evaluasi efek kombinasi ekstrak dari ketiga tanaman (chinaberry, malayan cherry, dan yacon) terhadap model hewan diabetes, untuk melihat potensi sinergis dalam meningkatkan efektivitas antidiabetik. Ketiga, penelitian perlu dilakukan untuk mengeksplorasi pengaruh metode ekstraksi yang berbeda terhadap kandungan senyawa bioaktif dan aktivitas antioksidan dari ketiga tanaman tersebut, sehingga dapat dioptimalkan proses ekstraksi untuk menghasilkan ekstrak dengan kualitas terbaik.

  1. The in-vitro Antioxidant Properties of Crude Drugs Traditionally Used for Diabetes Management in Northern... journal.ugm.ac.id/TradMedJ/article/view/76958The in vitro Antioxidant Properties of Crude Drugs Traditionally Used for Diabetes Management in Northern journal ugm ac TradMedJ article view 76958
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