IJRETINAIJRETINA

International Journal of RetinaInternational Journal of Retina

Introduction: To describe patient characteristics, bacterial patterns, management, and outcomes of therapy in patients with acute postoperative endophthalmitis. Methods: This observational, descriptive study was conducted at Dr. Saiful Anwar General Hospital in Malang, Indonesia, between 2020 and 2024, involving all patients with newly diagnosed acute postoperative endophthalmitis with a follow-up period at the patients initial visit, on day 7, and on day 28 following treatment. Result: A total of 74 patients were included in the study. The majority were male (51.3%), with a mean age of 61.57 ± 11.54 years. The most common comorbid was diabetes mellitus (16.2%). The etiology was most commonly due to gram-negative bacilli (13%), and phacoemulsification was the most common surgical procedure associated with endophthalmitis (74%). Quinolones exhibited the highest sensitivity. The most common management was a combination of medical and surgical treatments, including intravitreal antibiotic injections (59%) and a combination of intravitreal antibiotic injections and pars plana vitrectomy (PPV) (18%). The visual acuity outcomes revealed that 45,9% patients experienced improvement.

The incidence of endophthalmitis increases with advancing patient age, correlating with a higher frequency of cataract surgeries performed.Current management outcomes for endophthalmitis are favorable, reflecting improvements aligned with updated clinical guidelines.The comprehensive management of endophthalmitis will result in an improved visual outcome.

Penelitian lebih lanjut perlu dilakukan untuk mengidentifikasi faktor-faktor risiko spesifik yang berkontribusi terhadap perkembangan endophthalmitis pasca operasi pada pasien dengan komorbiditas tertentu, seperti diabetes mellitus, untuk mengembangkan strategi pencegahan yang lebih efektif. Selain itu, studi komparatif yang mengevaluasi efektivitas berbagai rejimen antibiotik intravitreal, termasuk kombinasi obat dan dosis yang berbeda, sangat penting untuk mengoptimalkan hasil pengobatan dan meminimalkan resistensi antibiotik. Terakhir, penelitian prospektif yang berfokus pada identifikasi biomarker prediktif untuk respons pengobatan dan prognosis pada pasien dengan endophthalmitis pasca operasi dapat membantu mempersonalisasi pendekatan terapeutik dan meningkatkan hasil visual jangka panjang. Penelitian-penelitian ini diharapkan dapat memberikan wawasan yang lebih mendalam tentang patogenesis, manajemen, dan pencegahan endophthalmitis, sehingga pada akhirnya meningkatkan kualitas perawatan pasien dan mengurangi beban penyakit.

  1. The Demographic Profile, Etiology and Outcomes of Acute Postoperative Endophthalmitis | International... doi.org/10.35479/ijretina.2025.vol008.iss002.330The Demographic Profile Etiology and Outcomes of Acute Postoperative Endophthalmitis International doi 10 35479 ijretina 2025 vol008 iss002 330
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