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Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal)

Acne infection is a skin condition induced by Propionibacterium acnes. Treatment of acne infection from natural ingredients native to Kalimantan such as Balik Angin or Alphitonia incana (Roxb.) Teijsm. & Binn. ex Kurz can be an alternative therapy. Prior research indicates that leaves macerated with methanol and 70% ethanol solvents can inhibit the growth of P.acnes in the medium category with a Minimum Inhibitory Concentration (MIC) of 3.2%. The research purpose is to compare the effect of the different solvents of soxhlet extraction on the antibacterial activity of Balik Angin leaves in inhibiting the growth of P.acnes. Balik Angin leaves were extracted using the Soxhlet with two different solvents, which were methanol and 70% ethanol, then followed by phytochemical screening. The antibacterial activity assay was carried out using well diffusion with each sample concentrations of 25.6%; 12.8%; 6.4%; 3.2%; 1.6%; 0.8%; 0.4%; and 0.2%. Both extracts contained the same phytochemical groups, which were phenols, tannins, saponins, and flavonoids, alkaloids, triterpenoids. The antibacterial activity test results showed that both extracts had the same MIC of 0.8%. however, the 70% ethanol extract of Balik Angin leaves was able to provide a larger inhibition diameter average of 9.61±0.35 mm compared to the methanol extract of 9.20±0.22 mm. Nonetheless, there was no significant difference (p>0.05) between both concentrations, when compared to the range of 1.6-25.6%.

The conclusion of this research is that differences in Soxhlet extraction solvents in Balik Angin leaves can affect its activity as an anti-Propionibacterium acnes agent.The study demonstrated that both methanol and 70% ethanol extracts effectively extracted equivalent groups of secondary metabolite compounds, including phenols, flavonoids, alkaloids, tannins, saponins, and triterpenoids.Furthermore, the 70% ethanol extract exhibited a more potent antibacterial activity against Propionibacterium acnes compared to the methanol extract.

Penelitian lebih lanjut perlu dilakukan untuk menguji efektivitas ekstrak daun Balik Angin dalam formulasi sediaan topikal, seperti krim atau gel, untuk pengobatan jerawat. Studi ini dapat mengevaluasi stabilitas, permeabilitas kulit, dan efek iritasi dari formulasi tersebut. Selain itu, penelitian perlu dilakukan untuk mengidentifikasi dan mengisolasi senyawa aktif spesifik dalam daun Balik Angin yang bertanggung jawab atas aktivitas antibakterinya, sehingga dapat dilakukan optimasi dan pengembangan senyawa tersebut sebagai agen anti-jerawat yang lebih efektif. Terakhir, penelitian lebih lanjut dapat mengeksplorasi potensi kombinasi ekstrak daun Balik Angin dengan antibiotik konvensional untuk meningkatkan efektivitas pengobatan jerawat dan mengurangi risiko resistensi bakteri, dengan mempertimbangkan interaksi sinergis atau aditif antara kedua agen tersebut.

  1. Pharmacognosy Communications - Open Access Peer-Reviewed Research Journal. open access peer reviewed... doi.org/10.5530/pc.2020.2.14Pharmacognosy Communications Open Access Peer Reviewed Research Journal open access peer reviewed doi 10 5530 pc 2020 2 14
  2. Evaluation of Antioxidant Activity and Phytochemical Screening of Leaves, Barks, Stems and Fruits of... doi.org/10.5530/pj.2019.11.151Evaluation of Antioxidant Activity and Phytochemical Screening of Leaves Barks Stems and Fruits of doi 10 5530 pj 2019 11 151
  3. UJI DAYA HAMBAT EKSTRAK ETANOL 70% BIJI PEPAYA (Carica papaya L.) TERHADAP BAKTERI Propionibacterium... e-journal.unper.ac.id/index.php/PHARMACOSCRIPT/article/view/400UJI DAYA HAMBAT EKSTRAK ETANOL 70 BIJI PEPAYA Carica papaya L TERHADAP BAKTERI Propionibacterium e journal unper ac index php PHARMACOSCRIPT article view 400
  4. Identification of Essential Oils From The Bark of Balik Angin (Alphitonia Incana (Roxb.) Teijsm. &... doi.org/10.24198/ijpst.v1i1.42498Identification of Essential Oils From The Bark of Balik Angin Alphitonia Incana Roxb Teijsm doi 10 24198 ijpst v1i1 42498
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