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UINUIN

Journal Pharmaceutical and Biomedical Sciences Journal (PBSJ)Pharmaceutical and Biomedical Sciences Journal (PBSJ) Abstract

Patients in the intensive care unit were often very sick and had lost consciousness. Because they had trouble swallowing, individuals with reduced awareness frequently depended on enteral tubes (NGT) for their daily medical and nutritional requirements. Since not all medications were accessible in parenteral forms, patients who relied on enteral tubes often had issues, including drug stability. Many problems arose in clinical usage when the medication was crushed or suspended and put into the NGT, including drug obstruction in the enteral tube and a reduction in drug stability as a result of the dose form being altered, making the drug unstable. Thus, this study aimed to ascertain the stability of oral suspension medications given to intensive care unit patients. The medical records of intensive care unit patients who had received oral medication therapy at X Hospital in Jakarta were examined retrospectively using a cross-sectional, descriptive approach. According to the statistics, coated tablets accounted for 68% of the most frequently used oral medication preparations. It was highly likely that crushing the coated tablets and administering them via NGT had resulted in tube obstruction. Additionally, 59.26% of the medications used had exhibited hygroscopic qualities, and several had been readily hydrolyzed. Based on these findings, it was concluded that oral medications, particularly crushed-coated tablets, could negatively affect drug stability. Active substances with hygroscopic properties and those prone to hydrolysis were also identified as potential contributors to instability.

Conclusion

The study concluded that solid oral drugs, especially crushed-coated tablets, could negatively impact drug stability.Active substances with hygroscopic and easily hydrolyzed properties were identified as potential contributors to instability.The findings highlighted the importance of considering drug stability when administering medications via enteral tubes, particularly for coated tablets.This research underscores the need for careful drug selection and formulation adjustments to ensure patient safety and therapeutic efficacy in ICU settings.

Future Research

Penelitian lebih lanjut perlu dilakukan untuk mengeksplorasi dampak penggunaan berbagai jenis pelarut dalam pembuatan suspensi obat terhadap stabilitas obat di lingkungan NGT. Studi komparatif yang membandingkan stabilitas obat dalam suspensi yang dibuat dengan air, larutan garam, atau pelarut lain dapat memberikan wawasan penting untuk praktik klinis. Selain itu, penelitian yang berfokus pada pengembangan formulasi obat yang lebih stabil dan mudah larut dalam air, khususnya untuk obat-obat yang sering digunakan di ICU, sangat diperlukan. Hal ini dapat mencakup penggunaan teknologi nano atau modifikasi molekul obat untuk meningkatkan kelarutan dan stabilitasnya. Terakhir, studi prospektif yang melibatkan pemantauan langsung terhadap pasien ICU yang menerima obat melalui NGT, dengan pengukuran kadar obat dalam darah dan penilaian klinis, dapat membantu mengidentifikasi masalah stabilitas obat secara real-time dan mengoptimalkan terapi obat.

References

1. A retrospective descriptive cross-sectional study of Oral Dosage Form Administered in The Form of Suspension... journal.uinjkt.ac.id/index.php/pbsj/article/view/41341A retrospective descriptive cross sectional study of Oral Dosage Form Administered in The Form of Suspension journal uinjkt ac index php pbsj article view 41341

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