JOURNAL JPSJOURNAL JPS

Journal of Pharmaceutical and SciencesJournal of Pharmaceutical and Sciences

This study aims to determine the protective activity of Bidens pilosa L. leaf ethanol extract (EEDK) on the immune system based on the white pulp diameter, and histopathology of the spleen of white rats given alcohol. The study was conducted experimentally using a completely randomized design (CRD), with treatments divided into 5 groups: negative control (K-) without EEDK or alcohol administration, positive control (K ) administered 10 ml/kg body weight of alcohol, treatment 1 (P1) administered 250 mg/kg body weight of EEDK and 10 ml/kg body weight of alcohol, treatment 2 (P2) given 500 mg/kgbb EEDK and 10 ml/kgbb alcohol, and treatment 3 (P3) given 750 mg/kgbb EEDK and 10 ml/kgbb alcohol. EEDK was administered 1 hour after alcohol administration and was given orally every day for 43 days. The parameters observed in this study were diameter of the white pulp, and histopathology of the white rat spleen. The observation data were analyzed using one-way ANOVA and followed by a post hoc test with the DMRT test to see the differences between treatments. The results showed that the ethanol extract Bidens pilosa L. potential as an immunomodulator by increasing the diameter of the white pulp of the spleen, and had a significant effect on spleen histology by showing protective activity with a decrease in the level of spleen tissue damage due to alcohol, particularly tissue fibrosis, lymphocyte apoptosis, and necrosis (p≤0.05).

The study concludes that ketul leaf ethanol extract (EEDK) possesses significant immunomodulatory properties by increasing the diameter of the white pulp of the spleen in alcohol-induced rats at a dose of 500 mg/kgBW.Furthermore, EEDK demonstrates protective effects by reducing histological damage to the spleen, specifically concerning tissue fibrosis, lymphocyte apoptosis, and lymphocyte necrosis, at a dose of 750 mg/kgBW.These findings suggest EEDKs potential as a safe and effective immunomodulator.

Further research should investigate the specific bioactive compounds within Bidens pilosa L. responsible for the observed immunomodulatory effects, potentially through metabolomic and proteomic analyses. Additionally, studies are needed to explore the long-term effects of EEDK administration on immune function and overall health, including assessments of cytokine profiles and immune cell populations over extended periods. Finally, research could focus on evaluating the efficacy of EEDK in combination with other therapeutic interventions for alcohol-induced immune dysfunction, examining potential synergistic effects and optimizing treatment strategies to improve patient outcomes. These investigations should be conducted using a variety of animal models and, ultimately, translated into clinical trials to assess the potential of EEDK as a novel therapeutic agent for mitigating the harmful effects of alcohol on the immune system.

  1. Protective effect ethanol extract of Bidens pilosa L. on the immune system based on histological spleen... journal-jps.com/new/index.php/jps/article/view/1183Protective effect ethanol extract of Bidens pilosa L on the immune system based on histological spleen journal jps new index php jps article view 1183
  2. Journal of Pharmaceutical and Sciences. journal sciences quick jump page content main navigation sidebar... doi.org/10.36490/journal-jps.comJournal of Pharmaceutical and Sciences journal sciences quick jump page content main navigation sidebar doi 10 36490 journal jps
  3. Effects of high dose of long-term ethanol exposure on oxidative damage of spleen in experimental rat... ijpas.org/index.php/ijpas/article/view/200Effects of high dose of long term ethanol exposure on oxidative damage of spleen in experimental rat ijpas index php ijpas article view 200
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