JOURNALMPCIJOURNALMPCI

Journal of Health and Nutrition ResearchJournal of Health and Nutrition Research

Type 2 diabetes mellitus is a metabolic disorder marked by chronic hyperglycemia and oxidative stress, which can reduce the activity of antioxidant enzymes like Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx). Acanthus ilicifolius (jeruju) contains antioxidant compounds such as flavonoids and phenolics that may enhance these enzyme activities. This study evaluated the effect of Acanthus ilicifolius leaf infusion on SOD and GPx activity in Wistar rats induced with type 2 diabetes using Streptozotocin-Nicotinamide (STZ-NA). The experimental design used a post-test only with five groups: normal control, positive control (diabetes metformin 45 mg/kgBW), negative control (diabetes without treatment), treatment group 1 (diabetes metformin 45 mg/kgBW jeruju infusion 1.2 ml/200gBW), and treatment group 2 (diabetes metformin 45 mg/kgBW jeruju infusion 2.4 ml/200gBW). Treatments were given daily for 30 days. The combination of Acanthus ilicifolius infusion and metformin, particularly at the 2.4 ml/200gBW dose, was associated with elevated SOD and GPx activities compared to the untreated diabetic group. These findings suggest that Acanthus ilicifolius infusion holds potential as an adjuvant therapy to mitigate oxidative stress in type 2 diabetes by enhancing SOD and GPx enzyme activities.

The study demonstrates that Jeruju (Acanthus ilicifolius) leaf infusion significantly enhances the activity of Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx) in STZ-NA-induced diabetic rats.4 ml/200gBW dose exhibited greater efficacy than the 1.2 ml/200gBW dose, indicating a dose-dependent effect.Further research is needed to explore the long-term effects and underlying molecular mechanisms of Jeruju in diabetes management.

Future research should investigate the specific bioactive compounds within Jeruju leaves responsible for the observed antioxidant effects, potentially through metabolomic and transcriptomic analyses. Furthermore, studies are needed to assess the efficacy of Jeruju infusion in different models of diabetes, including those more closely mimicking human disease progression, such as genetic models or those with varying durations of hyperglycemia. Finally, clinical trials are warranted to evaluate the safety and efficacy of Jeruju infusion as a complementary therapy for individuals with type 2 diabetes, examining its impact on glycemic control, oxidative stress markers, and diabetic complications. These investigations should also explore the potential synergistic effects of Jeruju with existing diabetes medications, optimizing treatment strategies for improved patient outcomes and quality of life.

  1. Jeruju (Acanthus ilicifolius) Leaf Infusion Modulates Superoxide Dismutase (SOD) and Glutathione Peroxidase... doi.org/10.56303/jhnresearch.v4i2.482Jeruju Acanthus ilicifolius Leaf Infusion Modulates Superoxide Dismutase SOD and Glutathione Peroxidase doi 10 56303 jhnresearch v4i2 482
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